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[Pathogenetic validation of optimal antioxidant therapy in suppurative inflammatory otic diseases in children]
K E Karabaev1, V F Antoniv, R U Bekmuradov
1Department of Otorhinolaryngology, University of People's Friendship, Russia.
Insights
Antioxidants like ascorbic acid, retinol, and alpha-tocopherol show promise in treating childhood middle ear infections. This study confirms their beneficial effects in reducing purulent inflammation.
Area of Science:
- Otolaryngology
- Pediatric Medicine
- Molecular Biology
Background:
- Middle ear inflammation (otitis media) is common in children.
- Understanding the cell-molecular basis of otitis media is crucial for effective treatment.
- Antioxidants may play a role in mitigating inflammatory processes.
Purpose of the Study:
- To investigate the potential therapeutic benefits of antioxidants in childhood middle ear inflammation.
- To evaluate the efficacy of a combined antioxidant treatment in pediatric patients.
Main Methods:
- A clinical trial was conducted involving children with purulent middle ear inflammation.
- Treatment involved a combination of ascorbic acid, retinol, and alpha-tocopherol.
- Patient response to the combined antioxidant therapy was assessed.
Main Results:
- The combined treatment with ascorbic acid, retinol, and alpha-tocopherol demonstrated a high response rate.
- Significant improvement was observed in children with purulent middle ear inflammation.
- The findings support the initial hypothesis regarding the beneficial effects of antioxidants.
Conclusions:
- Antioxidants, including ascorbic acid, retinol, and alpha-tocopherol, are beneficial in treating purulent middle ear inflammation in children.
- Combined antioxidant therapy offers a promising approach for managing pediatric otitis media.
- Further research into the molecular mechanisms is warranted.
Abstract:
The knowledge of cell-molecular characteristics of middle ear inflammation in children allowed the authors to suggest a beneficial effect of antioxidants in this disease. The trial of ascorbic acid, retinol and alpha-tocopherol as components of combined treatment has confirmed this hypophysis in view of high response achieved in children with middle ear purulent inflammation.