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Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cells

R G Carroll1, J L Riley, B L Levine

  • 1Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD 20850, USA.

Science (New York, N.Y.)
|April 11, 1997
PubMed

Activation of CD4(+) T lymphocytes from human immunodeficiency virus-type 1 (HIV-1)-infected donors with immobilized antibodies to CD3 and CD28 induces a virus-resistant state. This effect is specific for macrophage-tropic HIV-1. Transcripts encoding CXCR4/Fusin, the fusion cofactor used by T cell line-tropic isolates, were abundant in CD3/CD28-stimulated cells, but transcripts encoding CCR5, the fusion cofactor used by macrophage-tropic viruses, were not detectable. Thus, CD3/CD28 costimulation induces an HIV-1-resistant phenotype similar to that seen in some highly exposed and HIV-uninfected individuals.

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