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Human immunodeficiency virus-associated lymphomas

D J Straus1

  • 1Department of Medicine, Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

The Medical Clinics of North America
|March 1, 1997
PubMed
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Human immunodeficiency virus (HIV)-associated lymphomas are a growing concern. This review covers the epidemiology, pathology, clinical features, and treatment of these lymphomas, including CNS lymphomas and Hodgkin

Area of Science:

  • Oncology
  • Infectious Diseases
  • Immunology

Background:

  • Improved survival in individuals with human immunodeficiency virus (HIV) due to antiretroviral therapy and opportunistic infection treatment leads to an increasing incidence of HIV-associated lymphomas.
  • HIV-associated lymphomas represent a significant clinical challenge in immunocompromised patients.

Purpose of the Study:

  • To review current understanding of HIV-associated lymphomas, encompassing epidemiology, pathology, biological and clinical features, and treatment strategies.
  • To specifically address central nervous system (CNS) lymphomas in the context of HIV infection.
  • To discuss Hodgkin's disease in HIV-infected individuals.

Main Methods:

  • Literature review of current thinking on HIV-associated lymphomas.

Related Experiment Videos

  • Synthesis of information on epidemiology, pathology, and clinical presentation.
  • Review of treatment modalities for systemic and CNS lymphomas.

    • Main Results:

    • HIV-associated non-Hodgkin lymphomas (NHL) present unique epidemiological and pathological characteristics.
    • Central nervous system (CNS) lymphomas in HIV-infected individuals have distinct features and management considerations.
    • Hodgkin's disease also occurs in HIV-infected individuals, requiring specific attention.

    Conclusions:

    • Understanding the multifaceted aspects of HIV-associated lymphomas is crucial for effective management.
    • Advances in HIV treatment necessitate ongoing research into lymphoma pathogenesis and therapy.
    • Comprehensive review provides a foundation for addressing the growing problem of lymphomas in HIV-infected populations.