Related Experiment Video
Updated: Jul 31, 2026

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
Published on: November 24, 2014
Sufentanil with and without diazepam for coronary artery bypass graft surgery
A A Lina1, P J Dauchot, A H Anton
1Department of Anesthesiology, Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA.
Abstract:
We studied the sufentanil-sparing effect of diazepam for anesthesia induction and compared stress responses (hemodynamics, plasma catecholamine levels) and sufentanil and diazepam plasma levels during sufentanil anesthesia with or without diazepam. Sixteen aortocoronary bypass surgery patients were randomly assigned to receive diazepam (D) 100 micrograms/kg (Group DS) or not (Group S), then sufentanil (Sf) infused at 150 micrograms/min until unconsciousness (U). After tracheal intubation, the Sf dose for U (Sfu) was repeated, preceded in Group DS by D 150 micrograms/kg. Group DS patients require lower Sfu doses (2.01 +/- 0.23 micrograms/kg vs 4.87 +/- 0.63 micrograms/kg (P < 0.05) and plasma Sf levels (236 +/- 47 ng/100 ml vs 593 +/- 118 ng/100 ml (P < 0.01) and had similar or lower heart rate, systolic and diastolic blood pressure, rate-pressure product, and plasma norepinephrine levels than S patients. Linear regression of mean plasma norepinephrine and sufentanil levels gave correlation coefficients of -0.205 in S and -0.90 in DS (p < 0.05).
Related Concept Videos
Local Anesthetics: Clinical Application as Spinal Anesthesia
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Parenteral Anesthetics: Overview
Cardiopulmonary Resuscitation IV: Pharmacological Management

