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Cytokine pattern in the cerebrospinal fluid from patients with GBS and CIDP
S Sivieri1, A M Ferrarini, F Lolli
1Department of Neurological Sciences, University of Padua, Padova, Italy.
Journal of the Neurological Sciences
|March 20, 1997
Abstract:
Macrophage-colony stimulating factor (M-CSF) and, less frequently, IL-1 beta and IL-6 were detected in the cerebrospinal fluid (SF) from Guillain-Barré syndrome (GBS) patients. IL-1 alpha, IL-2, IL-10, TNF alpha, and IFN gamma were not found. Detectable cytokine levels were not observed in chronic inflammatory demyelinating polyneuropathy (CIDP) SF nor in any of the sera studied. These findings suggest a prominent intrathecal activation of cells of the monocyte/macrophage lineage (Mø) in GBS, and further support the hypothesis of a crucial role for Mø in GBS immunopathology.