Architecture and function in the muscle sarcomere
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Updated: Nov 2, 2026

Obtaining Quality Extended Field-of-View Ultrasound Images of Skeletal Muscle to Measure Muscle Fascicle Length
Published on: December 14, 2020
1Biophysics Section, Blackett Laboratory, Imperial College, London, SW7 2BZ, UK. j.squire@ic.ac.uk
Abstract:
Striated muscle sarcomeres in vertebrates comprise ordered arrays of actin and myosin filaments, organized by an elaborate protein scaffold. Recent innovative work in a number of laboratories has greatly improved our knowledge of these structures, their organization and their interactions. Structural details have been reported on myosin filaments, actin filaments, Z-bands, M-bands, titin, and nebulin. Time-resolved X-ray diffraction and electron microscopy are revealing the molecular movements involved in force production and regulation.
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