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Skin infiltration in acute promyelocytic leukemia
1Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Dermatology (Basel, Switzerland)
|January 1, 1997
Summary
Skin infiltration in acute promyelocytic leukemia (APL) is rare. This case study suggests changes in leukemic cell surface molecules after all-trans retinoic acid (ATRA) therapy may be linked to skin involvement.
Area of Science:
- Hematology
- Dermatology
- Oncology
Background:
- Acute promyelocytic leukemia (APL) is a distinct subtype of acute leukemia.
- Skin infiltration, or leukemia cutis, is an exceptionally rare manifestation of APL.
Observation:
- A 30-year-old woman with APL developed skin nodules during remission.
- Histopathology confirmed dense dermal infiltration by myeloperoxidase-positive atypical cells.
Findings:
- Immunophenotyping revealed altered surface molecule expression on APL cells post-all-trans retinoic acid (ATRA) treatment.
- Changes included acquisition of CD7 and CD41, and loss of CD3, CD4, CD5, CD8, and CD10.
Implications:
- The study suggests a correlation between ATRA-induced surface marker modulation and APL skin infiltration.
- Understanding these molecular changes could offer insights into APL pathogenesis and treatment strategies.