Ki-1 skin lymphoproliferative disorders: management with radiation therapy

Lymphomatoid papulosis and anaplastic large Ki-1 lymphoma of skin share unique clinical and pathological features. Appropriate therapy for multiple Ki-1 lymphoproliferative lesions without systemic involvement remains controversial. This paper presents results achieved with local radiation therapy. Two patients with multiple Ki-1 skin lymphoproliferative tumors were treated with local radiation using various techniques determined by the size and the depth of tumor invasion. Most lesions received 3000 cGy in 3 weeks. Complete response was achieved in all treated areas. There was virtually no morbidity. After more than 3 years, none of the treated areas developed local recurrence, and there was no evidence of internal dissemination. Ki-1 skin lymphoproliferative disorders are highly radiosensitive. When the disease is confined to the skin, and there is no evidence of spontaneous regression, or if palliation of symptoms is necessary, local radiation therapy may be an effective modality.