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(-)-Nicotine produces conditioned place preference in Lewis, but not Fischer 344 rats
B Horan1, M Smith, E L Gardner
1Department of Pharmaceutical Sciences, St. John's University, Jamaica, New York 11439, USA.
Abstract:
In this study, we sought to determine if Fischer 344 (F344) and Lewis rats showed different conditioned place preference (CPP) responses to subcutaneously administered (-)-nicotine. Lewis rats displayed a CPP response to (-)-nicotine after five pairings, whereas F344 rats showed no preference for nicotine compared to vehicle. After 10 pairings, the F344 rats showed a conditioned place aversion to (-)-nicotine, whereas the Lewis rats still displayed a significant CPP response. These results suggest that the differences in appetitiveness shown between Lewis and F344 rats to other drugs of abuse extend also to (-)-nicotine.