Related Experiment Video
Updated: Jul 29, 2026
11:38
A Flow Adhesion Assay to Study Leucocyte Recruitment to Human Hepatic Sinusoidal Endothelium Under Conditions of Shear Stress
Published on: March 21, 2014
Circulating intercellular adhesion molecule-1 in endemic chronic liver diseases
I M el-Gindy1, A Tharwat, N M Fahim
1Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.
Journal of the Egyptian Society of Parasitology
|April 1, 1997
Summary
Serum levels of intercellular adhesion molecule-1 (ICAM-1) indicate immune activation. Higher ICAM-1 levels in chronic liver disease patients correlate with liver damage and inflammation severity.
Area of Science:
- Immunology
- Hepatology
- Biochemistry
Background:
- Soluble intercellular adhesion molecule-1 (ICAM-1) is released during inflammation from leukocytes and endothelial cells.
- Serum ICAM-1 levels can indicate immune activation and inflammatory processes.
Purpose of the Study:
- To measure serum ICAM-1 levels in patients with chronic liver diseases.
- To correlate ICAM-1 levels with liver histology and function.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to quantify serum ICAM-1.
- Forty patients with endemic chronic liver diseases were studied.
Main Results:
- Serum ICAM-1 was significantly higher in chronic active liver disease patients compared to controls.
- ICAM-1 levels positively correlated with histological activity grade and cirrhosis presence.
- A significant positive correlation was observed between ICAM-1 and alanine aminotransferase (ALT) levels.
Conclusions:
- Serum ICAM-1 concentration reflects hepatocellular damage in chronic liver disease.
- Serum ICAM-1 may be valuable for investigating, diagnosing, and monitoring inflammatory liver conditions.
More Related Videos
08:56Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
11:44Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice
Published on: March 24, 2015
Related Concept Videos
01:24Liver Regeneration
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
01:24Chronic Pancreatitis I: Introduction
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:12Chronic Inflammation: Introduction
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
01:23Cirrhosis I: Introduction
Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
01:24Cirrhosis II: Pathophysiology
Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
01:19Ascites
DefinitionAscites is the buildup of fluid inside the peritoneal cavity. It occurs when fluid moves out of the vascular system faster than the peritoneal lymphatics can remove it. This fluid shift is most commonly seen in liver cirrhosis but can also appear in several other systemic disorders.EtiologyCirrhosis remains the leading cause of ascites. Other conditions that can contribute include:Heart failureConstrictive pericarditisAbdominal cancersNephrotic syndromeSevere protein–calorie...