Morphological and clinical aspects of membrano-proliferative glomerulonephritis in children

Clinical and morphological studies were carried out in 34 children with the diagnosis of primary membrano-proliferative glomerulonephritis. The studies were prompted by an increasing incidence of this type of glomerulonephritis in Poland in the light of its regular decrease in the world. We found: (a) a number of discrepancies in the clinical manifestations and course of the disease in our children as compared with those in the literature; (b) difficulties in morphological diagnosis; (c) a frequent lack of correlation between the severity of morphological changes and the clinical course. It is of note that our series includes a large group of children below 6 years of age, which is a rare phenomenon.