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[Calcitonin and bone aging]

J Y Reginster1

  • 1Centre Universitaire d'Investigation du Métabolisme Osseux et du Cartilage Articulaire, Université de Liège, Belgique.

Pathologie-Biologie
|January 1, 1997
PubMed
Summary

Salmon calcitonin effectively prevents bone loss and reduces fracture risk in postmenopausal women. Nasal administration is a rational solution for osteoporosis prevention and treatment.

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Area of Science:

  • Endocrinology
  • Bone Biology
  • Pharmacology

Context:

  • Menopause-induced trabecular bone loss is a significant concern.
  • Osteoporosis treatment requires effective and safe therapeutic options.

Purpose:

  • To review the efficacy of salmon calcitonin in preventing and treating bone loss and fractures.
  • To evaluate different administration routes and dosages of calcitonin.

Summary:

  • Nasal salmon calcitonin (100 IU/day) prevents menopausal bone loss; lower doses may suffice, while higher doses increase spinal bone mineral content.
  • Calcitonin, especially at higher doses, requires systemic calcium supplementation. Rectal and parenteral routes are also effective.
  • Long-term nasal calcitonin increases spinal bone mass; discontinuous therapy benefits cortical bone. It significantly reduces fracture frequency and offers analgesic effects in established osteoporosis.

Impact:

  • Salmon calcitonin is a rational choice for preventing and treating postmenopausal osteoporosis.
  • Evidence supports calcitonin's role in reducing vertebral and hip fractures.
  • Nasal calcitonin improves pain management and reduces immobility in osteoporosis patients.

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