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Gastrointestinal permeability in celiac disease
E Smecuol1, J C Bai, H Vazquez
1Department of Gastroenterology, Salvador University, Buenos Aires, Argentina.
Gastroenterology
|April 1, 1997
Summary
Sucrose permeability testing effectively detects active celiac disease, showing increased sucrose excretion in most patients. This marker rapidly improves with a gluten-free diet, aiding in monitoring treatment response.
Area of Science:
- Gastroenterology
- Clinical Diagnostics
- Biomarker Research
Background:
- Intestinal permeability is elevated in active celiac disease.
- Sucrose permeability is a novel method for assessing upper gastrointestinal damage.
- Evaluating sucrose permeability for celiac disease detection is crucial.
Purpose of the Study:
- To assess the efficacy of sucrose permeability testing in identifying celiac disease.
- To compare sucrose permeability with conventional methods for diagnosing celiac disease.
Main Methods:
- Sucrose permeability tests were conducted on 27 newly diagnosed celiac patients before and after a gluten-free diet.
- Results were compared to 30 healthy subjects and 7 patients with chronic diarrhea.
- Lactulose-mannitol ratio was also assessed.
Main Results:
- 25/27 patients exhibited increased sucrose excretion at diagnosis.
- Mean sucrose excretion was significantly higher in untreated celiac patients versus controls.
- Sucrose excretion normalized in 60% of patients after treatment, while lactulose-mannitol ratios remained abnormal.
Conclusions:
- Elevated sucrose permeability is a sensitive indicator of advanced celiac disease.
- Sucrose permeability decreases rapidly with a gluten-free diet, making it useful for monitoring therapy response.