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Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Related Experiment Video

Updated: Jul 27, 2026

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

Published on: May 2, 2012

Myocardial viability studies using fluorine-18-FDG SPECT: a comparison with fluorine-18-FDG PET

E Q Chen¹, W J MacIntyre, R T Go

¹Department of Nuclear Medicine, Cleveland Clinic Foundation, OH 44195, USA.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine

|April 1, 1997

Summary

Single-photon emission computed tomography (SPECT) with a dedicated 511-keV collimator provides a cost-effective alternative for myocardial viability assessment using [18F]FDG, showing good agreement with PET. Standard high-energy SPECT is inadequate for these studies.

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High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

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Published on: December 16, 2022

Area of Science:

Nuclear medicine
Cardiovascular imaging
Radiopharmaceuticals

Background:

Positron emission tomography (PET) is the standard for myocardial viability studies using [18F]FDG.
Multidetector single-photon emission computed tomography (SPECT) systems with specialized collimators are being explored as a less expensive alternative.

Purpose of the Study:

To measure and compare the physical imaging characteristics of SPECT systems (high-energy general-purpose [HE] and dedicated 511-keV [UH] collimators) with FDG PET.
To quantitatively compare the diagnostic accuracy of SPECT (UH and HE collimators) versus PET for myocardial viability using [18F]FDG.

Main Methods:

Physical imaging characteristics of SPECT and PET were assessed.
Two groups of 18 patients underwent [18F]FDG SPECT (Group I: HE, Group II: UH) and [82Rb]PET for perfusion.
Perfusion-metabolism match/mismatch patterns were determined for myocardial regions with perfusion defects.

Main Results:

PET demonstrated superior sensitivity and contrast resolution compared to SPECT.
The 511-keV (UH) collimator improved SPECT spatial and contrast resolution and reduced septal penetration compared to the high-energy (HE) collimator.
SPECT with UH collimator showed excellent agreement (kappa = 0.736) with PET for viability, while HE collimator showed moderate agreement (kappa = 0.413).

Conclusions:

SPECT with a dedicated 511-keV collimator is a practical, low-cost alternative to PET for [18F]FDG myocardial viability studies.
SPECT systems with high-energy general-purpose collimators are not suitable for these assessments.
The UH collimator significantly enhances SPECT's utility in myocardial viability imaging.