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Drug-induced movement disorders

F J Jiménez-Jiménez¹, P J García-Ruiz, J A Molina

¹Department of Neurology, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.

|March 1, 1997

Summary

Many drugs can cause movement disorders like Parkinsonism and tardive dyskinesia. These drug-induced movement disorders are sometimes irreversible, even after medication cessation.

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Area of Science:

Neurology
Pharmacology

Background:

Drug-induced movement disorders (DIMDs) encompass a range of conditions including parkinsonism, tremor, chorea-ballismus, dystonia, tardive dyskinesia, myoclonus, tics, and akathisia.
Numerous medications are associated with the development of these movement disorders.

Purpose of the Study:

To review the spectrum of movement disorders that can be induced by various medications.
To identify the drug classes most commonly implicated in causing these adverse effects.

Main Methods:

Literature review of drug-induced movement disorders.
Analysis of drug classes frequently associated with movement abnormalities.

Main Results:

Antipsychotics, calcium antagonists, orthopramides, and substituted benzamides (e.g., metoclopramide, sulpiride) are among the most frequent culprits.
Central nervous system stimulants, antidepressants, anticonvulsants, antiparkinsonian drugs, and lithium also contribute to DIMDs.
A single drug may precipitate multiple types of movement disorders in a patient.

Conclusions:

A wide array of drugs can induce various movement disorders.
The potential for drug-induced movement disorders necessitates careful medication management and monitoring.
These movement disorders may not resolve even after the offending drug is discontinued.

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