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[2nd generation bio-integrated keratoprosthesis. Implantation in animals]
J M Legeais1, I Drubaix, B Briat
1Service d'Ophtalmologie, Hôtel-Dieu de Paris.
Journal Francais D'Ophtalmologie
|January 1, 1997
Summary
The second-generation BioKpro II keratoprosthesis shows successful implantation potential in rabbits. Further research is needed to optimize surface modifications for epithelial cell attachment and prevent necrosis.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Surgical Innovation
Context:
- Corneal blindness necessitates advanced prosthetic solutions.
- Evaluating next-generation biointegrable keratoprosthetic devices is crucial for improving patient outcomes.
- The BioKpro II aims to overcome limitations of earlier keratoprostheses.
Purpose:
- To assess the safety and efficacy of the second-generation biointegrable keratoprosthetic device (BioKpro II).
- To evaluate the biomechanical properties and integration of the BioKpro II in a rabbit model.
- To identify potential complications and necessary modifications for successful implantation.
Summary:
- The BioKpro II, featuring a porous PTFE flange and soft copolymer optic, was implanted in 14 rabbits.
- Intraocular pressure was measured, and outcomes were monitored for three months.
- Epithelialization of the optical surface was not observed; aseptic necrosis occurred when conjunctiva coverage was insufficient, highlighting the need for protective tissue grafts.
Impact:
- The BioKpro II demonstrates promising biomechanical compatibility with corneal tissue.
- Successful implantation suggests potential for treating corneal blindness.
- Further surface modifications are proposed to enhance epithelial integration and prevent device-related complications like ulceration.