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Spiking fevers with clozapine treatment
F Trémeau1, S C Clark, D Printz
1Department of Clinical Psychobiology, New York State Psychiatric Institute, New York 10032, USA.
Clinical Neuropharmacology
|April 1, 1997
Summary
Spiking fever is a newly identified side effect of clozapine therapy, occurring within the first three weeks. This, along with respiratory, gastrointestinal symptoms, and neutrophilia, warrants further investigation into clozapine
Area of Science:
- Pharmacology
- Clinical Medicine
- Toxicology
Background:
- Clozapine is an atypical antipsychotic medication.
- Fever is a known, though infrequent, side effect of clozapine.
- The incidence and specific presentation of clozapine-induced fever require further elucidation.
Observation:
- Three cases of spiking fever during early clozapine treatment (within 3 weeks) are presented.
- Associated symptoms included respiratory and gastrointestinal issues.
- Neutrophilia was observed in conjunction with fever.
Findings:
- Early-onset spiking fever is a potential adverse reaction to clozapine.
- A distinct cluster of side effects, including fever, GI/respiratory symptoms, and neutrophilia, may indicate a specific adverse reaction.
- The findings suggest a need for heightened monitoring during initial clozapine administration.
Implications:
- Clinicians should be vigilant for spiking fever and associated symptoms in patients initiating clozapine.
- Early identification of this side effect may prevent serious complications.
- Further research into the mechanisms underlying clozapine-induced fever and related symptoms is warranted.