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Mechanisms of selection and differentiation in germinal centers
Y J Liu1, O de Bouteiller, I Fugier-Vivier
1Schering-Plough, Laboratory for Immunological Research, Dardilly, France. HJ.Liu@sch-plough.fr
Current Opinion in Immunology
|April 1, 1997
Abstract:
The choice between death and survival, a feature of early B cell development, is a choice also faced by mature B cells. If they survive this early developmental decision, mature B cells then face a second choice: either to undergo either terminal differentiation into plasma cells or to differentiate into memory B cells. Antigens, T cell signals (cytokines, CD40 ligand and Fas ligand) as well as the activation state of B cells determine their ultimate fate.