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Related Experiment Videos

90K (Mac-2 BP) in human milk

N D'Ostilio1, G Sabatino, C Natoli

  • 1Cattedra di Oncologia Medica, Università G. D' Annunzio, Chieti, Italy.

Clinical and Experimental Immunology
|June 1, 1996
PubMed
Summary

Human 90K (Mac-2 binding protein) is found in breast milk, peaking 2-3 days postpartum. Its concentration in milk did not correlate with maternal blood levels.

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Area of Science:

  • Biochemistry
  • Immunology
  • Human Physiology

Background:

  • Human 90K, or Mac-2 binding protein (Mac-2 BP), is a secreted glycoprotein involved in host defense.
  • It binds to the macrophage-associated lectin Mac-2.

Purpose of the Study:

  • To measure the concentrations of Human 90K in human breast milk.
  • To investigate the relationship between 90K levels in breast milk and maternal blood.

Main Methods:

  • Specific immunoenzymatic assay used to quantify 90K concentrations.
  • Samples collected from eight healthy mothers of full-term infants.

Main Results:

  • Maximal 90K concentrations in breast milk ranged from 13.4 to 79.2 microg/ml.
  • Peak concentrations were observed on days 2-3 post-partum.
  • No correlation was found between 90K levels in breast milk and maternal blood.

Conclusions:

  • Human 90K is present in significant concentrations in early postpartum breast milk.
  • Breast milk 90K levels are independent of maternal serum levels in the early postpartum period.

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