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Endometrial involvement by multiple myeloma

N L Smith1, D B Baird, P H Strausbauch

  • 1Department of Pathology and Laboratory Medicine, East Carolina University, School of Medicine, Greenville, North Carolina, USA.

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
|April 1, 1997
PubMed
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Multiple myeloma, a plasma cell cancer, can rarely affect the uterus. This case highlights neoplastic plasma cell infiltration of the endometrium causing abnormal uterine bleeding.

Area of Science:

  • Hematology
  • Gynecologic Oncology
  • Oncology

Background:

  • Multiple myeloma is a malignant proliferation of plasma cells.
  • It typically affects the bone marrow but can have extramedullary manifestations.
  • Extramedullary involvement can present with diverse clinical symptoms.

Observation:

  • A 79-year-old woman with known multiple myeloma presented with abnormal uterine bleeding.
  • Serum analysis revealed immunoglobulin G-kappa paraprotein and kappa light chain Bence-Jones proteinuria.
  • Endometrial biopsy was performed due to persistent abnormal uterine bleeding.

Findings:

  • Histopathological examination of the endometrium showed extensive infiltration by large, atypical cells.
  • These atypical cells were identified as neoplastic plasma cells.

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  • The findings confirmed extramedullary endometrial involvement by multiple myeloma.

    • Implications:

    • This case demonstrates a rare presentation of multiple myeloma involving the endometrium.
    • Endometrial involvement by multiple myeloma can manifest as abnormal uterine bleeding.
    • Clinicians should consider extramedullary myeloma in the differential diagnosis of abnormal uterine bleeding in patients with known multiple myeloma.