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Effect of Rhazya stricta on the developing rat fetus
R A Rasheed1, A K Bashir, B H Ali
1Desert And Marine Environment Research Center, United Arab Emirates University, Al-Ain, United Arab Emirates.
Reproductive Toxicology (Elmsford, N.Y.)
|March 1, 1997
Summary
Rhazya stricta extract can harm fetal development in rats, especially at later pregnancy stages. High doses caused reduced fetal weight, growth retardation, and resorption, indicating potential pregnancy risks.
Area of Science:
- Pharmacology
- Toxicology
- Reproductive Biology
Background:
- Rhazya stricta is a traditional medicinal herb.
- Its use for diabetes, inflammation, and helminthiasis is documented.
- Potential effects on fetal development require investigation.
Purpose of the Study:
- To evaluate the impact of Rhazya stricta extract on rat fetal development.
- To identify potential risks associated with its administration during pregnancy.
Main Methods:
- Administered lyophilized Rhazya stricta extract to pregnant rats on specific gestation days (GD).
- Examined fetuses on GD 20 for weight, viability, and malformations.
- Assessed maternal weight gain and placental development.
Main Results:
- Higher doses reduced maternal weight gain.
- Treatment on later GDs (8-15) decreased live fetuses and fetal weight.
- Pronounced intrauterine growth retardation (IUGR) and extreme resorption occurred at later stages.
- Retarded placental development with hypovascularity was observed.
- Malformations did not reach statistical significance, but generalized growth retardation was noted.
Conclusions:
- Rhazya stricta extract exhibits potential fetal toxicity in rats.
- Administration during later pregnancy stages poses risks, including IUGR and fetal death.
- Further research is needed to understand the mechanisms and confirm safety in humans.