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Related Experiment Videos

Heat intolerance induced by antidepressants

Y Epstein1, D Albukrek, B Kalmovitc

  • 1Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer, Israel.

Annals of the New York Academy of Sciences
|March 15, 1997
PubMed
Summary

Fluoxetine and lithium carbonate can cause heat intolerance, leading to heat stroke. This case highlights the risk of heat-related illness in patients taking these medications, even with mild exertion.

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Area of Science:

  • Clinical Toxicology
  • Environmental Medicine
  • Neuroscience

Background:

  • Depression treatment often involves multiple medications.
  • Drug interactions can lead to unexpected adverse effects.
  • Heat intolerance is a known side effect of some psychotropic medications.

Observation:

  • A patient on fluoxetine and lithium carbonate developed heat intolerance.
  • The patient experienced heat stroke during mild exertion in hot, dry conditions.
  • Symptoms included loss of consciousness, hyperthermia, and disseminated intravascular coagulation.

Findings:

  • This is the first reported case of heat intolerance from combined fluoxetine and lithium carbonate.
  • Drug-induced heat intolerance reduced the patient's ability to tolerate exercise-heat stress.

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  • Excessive heat accumulation occurred due to medication side effects and environmental factors.

    • Implications:

    • Clinicians should consider heat intolerance when prescribing fluoxetine and lithium carbonate concurrently.
    • Patients on these medications require counseling on heat exposure risks.
    • Further research is needed to understand the mechanisms of drug-induced heat intolerance.