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Absolute bioavailability of bromfenac in humans
K Gumbhir-Shah1, W H Cevallos, S A DeCleene
1Wyeth-Ayerst Research, Philadelphia, PA 19101, USA.
The Annals of Pharmacotherapy
|April 1, 1997
Summary
This study found that bromfenac has an absolute bioavailability of 67%, indicating similar pharmacokinetic profiles whether given intravenously or orally. This suggests the oral form is effective for drug delivery.
Area of Science:
- Pharmacology
- Clinical Pharmacy
Background:
- Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID).
- Understanding its bioavailability and pharmacokinetics is crucial for effective therapeutic use.
Purpose of the Study:
- To determine the absolute bioavailability of bromfenac.
- To compare the pharmacokinetic characteristics of bromfenac following intravenous and oral administration.
Main Methods:
- A randomized, open-label, single-dose, crossover study was performed.
- Twelve healthy subjects received 50-mg doses of bromfenac intravenously and orally, with a 48-hour washout period.
- Plasma concentrations were analyzed using HPLC with UV detection.
Main Results:
- The mean absolute bioavailability of bromfenac was determined to be 67% (±20%).
Conclusions:
- Pharmacokinetic parameters for bromfenac were comparable between intravenous and oral routes.
- The oral dosage form appears optimal, with intersubject variability attributed to the drug itself.
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