Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Digoxin-itraconazole interaction: possible mechanisms

C P Alderman1, P D Allcroft

  • 1Repatriation General Hospital, Daw Park, South Australia.

The Annals of Pharmacotherapy
|April 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A brief analysis of clinical pharmacy interventions undertaken in an Australian teaching hospital.

Journal of quality in clinical practice·2002
Same author

Understanding antipsychotic drug tolerability.

The Annals of pharmacotherapy·2002
Same author

Possible interaction of zopiclone and nefazodone.

The Annals of pharmacotherapy·2001
Same author

Characteristics of tranquilizer use among Australian Vietnam War veterans.

The Annals of pharmacotherapy·2000
Same author

Possible neuroleptic malignant syndrome associated with olanzapine.

The Annals of pharmacotherapy·2000
Same author

Patient-oriented strategies for the prevention of drug interactions.

Drug safety·2000

Concurrent use of itraconazole with digoxin may decrease digoxin clearance, leading to elevated serum digoxin levels. Healthcare providers should monitor digoxin concentrations when these medications are co-administered.

Area of Science:

  • Pharmacology
  • Nephrology

Background:

  • Digoxin is a cardiac glycoside used for atrial fibrillation.
  • Renal clearance, involving glomerular filtration and tubular secretion, is key to digoxin elimination.

Observation:

  • A patient on digoxin for atrial fibrillation was treated with itraconazole for esophageal candidiasis.
  • Concurrent therapy showed a decrease in estimated urinary digoxin clearance.

Findings:

  • Itraconazole administration was associated with a reduction in digoxin clearance.
  • This interaction potentially increased serum digoxin concentration.

Implications:

  • Clinicians should monitor serum digoxin levels in patients receiving both digoxin and itraconazole.
  • Further research is needed to understand the itraconazole-digoxin interaction mechanism.

Related Experiment Videos