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Related Experiment Videos

Herpes zoster brachial plexus neuritis

V A Fabian1, B Wood, P Crowley

  • 1Department of Neuropathology, Royal Perth Hospital, Western Australia.

Clinical Neuropathology
|March 1, 1997
PubMed
Summary

This study reveals brachial plexus inflammation as a cause of herpes zoster-related arm weakness. The findings suggest an inflammatory demyelinative process in brachial plexus neuritis.

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Area of Science:

  • Neurology
  • Immunology
  • Pathology

Background:

  • Herpes zoster (shingles) can cause neurological complications.
  • Motor involvement in herpes zoster is less understood than sensory complications.

Observation:

  • A 78-year-old female with herpes zoster developed left upper arm monoplegia.
  • Post-mortem examination revealed brachial plexus inflammation and demyelination.

Findings:

  • Histology showed lymphocytic infiltration and myelin breakdown in the brachial plexus.
  • Cervical spinal cord exhibited perivascular lymphocytic cuffing without anterior horn necrosis.
  • Brachial plexus inflammation is proposed as a distal extension of dorsal ganglionitis.

Implications:

  • Brachial plexus neuritis may directly cause reversible upper limb paresis in herpes zoster patients.
  • The motor neuropathy is an inflammatory demyelinative process.
  • Post-herpetic neuralgia might stem from an ongoing inflammatory process.

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