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Experimental vitreous replacement with perfluorophenanthrene

R Ratiglia1, E Berti, D Galimberti

  • 11st Institute of Ophthalmology, University of Milano, Ospedale Maggiore of Milano, Italy.

European Journal of Ophthalmology
|January 1, 1997
PubMed
Summary
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Perfluorophenanthrene (PFP) caused progressive damage to rabbit eyes, altering chorioretinal structure and involving glia cells in inflammation. This suggests PFP is not well-tolerated as an intraocular tamponade.

Area of Science:

  • Ophthalmology
  • Retinal Surgery
  • Toxicology

Background:

  • Intraocular tamponade substances are crucial in retinal surgery.
  • Perfluorophenanthrene (PFP) has been considered for internal tamponade due to its properties.
  • Understanding the ocular toxicity of PFP is essential for its safe application.

Purpose of the Study:

  • To evaluate the toxicity of perfluorophenanthrene (PFP) on rabbit choroid and retina.
  • To determine if PFP is tolerated as an intraocular tamponade or causes retinal damage.
  • To investigate whether PFP-induced damage is due to direct toxicity or emulsification-mediated phagocytosis.

Main Methods:

  • Vitrectomy was performed on 24 rabbit eyes, with 0.8-1 ml of PFP instilled as a tamponade.
  • A control group of 12 rabbit eyes underwent vitrectomy with balanced salt solution.

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  • Ophthalmoscopy, histological, and immunohistochemical examinations were conducted at various time points post-surgery.

    • Main Results:

    • Histological examination revealed progressive damage to chorioretinal tissues starting from the second week.
    • Complete alteration of the chorioretinal structure was observed by the eighth week.
    • Immunohistochemical analysis indicated glial cell involvement in the inflammatory response.

    Conclusions:

    • Perfluorophenanthrene (PFP) causes progressive and severe damage to the chorioretinal tissues.
    • The inflammatory response involves glial cells, suggesting a toxic or reactive process.
    • PFP is not well-tolerated as an intraocular tamponade substance in rabbits.