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Screening for twin pregnancy

L Jovanovic, R Landesman, B B Saxena

    Science (New York, N.Y.)
    |November 18, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Elevated human chorionic gonadotropin (hCG) levels in early pregnancy can indicate a twin pregnancy. This simple test aids in early detection, allowing for timely prenatal care.

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    Area of Science:

    • Reproductive Endocrinology
    • Maternal-Fetal Medicine
    • Clinical Chemistry

    Background:

    • Early pregnancy diagnosis relies on various biomarkers.
    • Human chorionic gonadotropin (hCG) is a key pregnancy hormone.
    • Distinguishing multiple gestations early is crucial for optimal outcomes.

    Purpose of the Study:

    • To evaluate serum hCG levels as a predictor of twin pregnancy.
    • To assess the feasibility of using hCG for early twin detection.
    • To compare hCG levels in singleton versus twin pregnancies.

    Main Methods:

    • Recruited 590 pregnant women 4-5 weeks post-LMP.
    • Measured serum hCG levels using radioreceptor assay.
    • Utilized pelvic sonography at 12 weeks gestation for confirmation.

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    Main Results:

    • Nine women presented with serum hCG levels approximately twofold higher than average.
    • Pelvic sonography confirmed twin pregnancies in all nine of these women.
    • No significant difference in hCG levels was noted in the remaining singleton pregnancies.

    Conclusions:

    • Serum hCG levels can serve as a simple and rapid indicator for suspected twin pregnancies.
    • Early identification of twin gestations via hCG levels facilitates prompt clinical management.
    • This method offers a cost-effective approach to early twin pregnancy screening.