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Related Experiment Videos

Systemic amyloidosis with temporal artery involvement mimicking temporal arteritis

E B Ing1, I Z Woolf, B R Younge

  • 1Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA.

Ophthalmic Surgery and Lasers
|April 1, 1997
PubMed
Summary

Systemic amyloidosis can mimic temporal arteritis in older men. Negative temporal artery biopsy results prompted further investigation, revealing amyloidosis secondary to multiple myeloma.

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Area of Science:

  • Internal Medicine
  • Rheumatology
  • Hematology

Background:

  • Giant cell arteritis (GCA), or temporal arteritis, is a common vasculitis in older adults.
  • Clinical presentation of GCA includes jaw claudication, arthralgias, myalgias, weight loss, and fatigue.
  • Temporal artery biopsy is the gold standard for diagnosing GCA.

Observation:

  • A 77-year-old man presented with symptoms suggestive of temporal arteritis.
  • Temporal artery biopsy showed no evidence of vasculitis.
  • Amyloidosis was suspected and confirmed via Congo red staining.

Findings:

  • Bone marrow biopsy revealed multiple myeloma.
  • The patient was diagnosed with systemic amyloidosis secondary to multiple myeloma.
  • The initial presentation was misleading, mimicking temporal arteritis.

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Implications:

  • Systemic amyloidosis should be considered in the differential diagnosis of patients presenting with symptoms suggestive of temporal arteritis, especially when temporal artery biopsy is negative for vasculitis.
  • This case highlights the importance of considering alternative diagnoses when initial investigations do not align with suspected conditions.
  • Early and accurate diagnosis of systemic amyloidosis is crucial for appropriate management and improved patient outcomes.