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["As much as possible"--an outdated concept in advanced neuroblastoma?]
S Simon1, H P Hümmer, R Carbon
1Abteilung für Kinderchirurgie, Chirurgische Universitätsklinik Erlangen.
Langenbecks Archiv Fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft Fur Chirurgie. Kongress
|January 1, 1996
Summary
Complete tumor resection is challenging in advanced neuroblastoma. Preoperative chemotherapy can improve resection rates and reduce complications in stages III and IV neuroblastoma.
Area of Science:
- Pediatric Oncology
- Surgical Oncology
Context:
- Disseminated neuroblastoma, particularly stages III and IV, presents challenges for complete tumor resection.
- A retrospective study analyzed 66 neuroblastoma patients operated between 1972 and 1995, focusing on 25 with disseminated disease.
Purpose:
- To evaluate the role and outcomes of primary tumor resection in neuroblastoma patients with disseminated stages (III and IV).
- To assess the effectiveness of preoperative chemotherapy in improving complete tumor resection rates.
Summary:
- Complete tumor resection (RO) was achieved in only 16% of disseminated neuroblastoma cases.
- Incomplete resections (R1/R2) were common, with high mortality rates across stages III, IV, and IV-S.
- Preoperative chemotherapy followed by delayed resection improved complete resection in two cases.
Impact:
- Recommends preoperative chemotherapy for infiltrative stage III and all stage IV neuroblastomas.
- Suggests this approach can enhance complete tumor resection rates and decrease intraoperative complications.