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[Isolated hyperthermic perfusion of extremities in malignant melanoma with melphalan and tumor necrosis factor]
C Kettelhack1, P Hohenberger, P M Schlag
1Humboldt-Universität, Virchow-Klinikum, Robert-Rössle-Klinik, Berlin.
Langenbecks Archiv Fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft Fur Chirurgie. Kongress
|January 1, 1996
Abstract:
Isolated limb perfusion (ILP) with tumor necrosis factor (TNF) and melphalan was carried out in 21 patients with regionally metastatic malignant melanoma of the limbs. The observed response rate was 65% complete and 15% partial remission. These results warrant further investigation of ILP with TNF and melphalan vs ILP with melphalan alone in a prospective randomised multicenter trial.