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[Immunomodulation after parenteral glutamine administration in colorectal surgery]
B J Morlion1, H P Siedhoff, U Joosten
1Klinik für Anästhesiologie und operative Intensivmedizin, Ruhr-Universität Bochum.
Langenbecks Archiv Fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft Fur Chirurgie. Kongress
|January 1, 1996
Summary
Parenteral glutamine supplementation normalized neutrophil function, specifically cysteinyl-leukotriene (cys-LT) synthesis, in post-surgery patients. This highlights glutamine
Area of Science:
- Immunology
- Surgical Nutrition
- Biochemistry
Background:
- Neutrophil dysfunction can impair host defense post-surgery.
- Cysteinyl-leukotrienes (cys-LT) are key mediators of inflammatory responses.
- Parenteral nutrition often involves amino acid supplementation.
Purpose of the Study:
- To investigate the effect of L-alanyl-L-glutamine dipeptide on neutrophil cys-LT synthesis post-colonic surgery.
- To determine if glutamine supplementation can normalize impaired neutrophil function after surgery.
Main Methods:
- Studied patients undergoing colonic surgery.
- Administered parenteral L-alanyl-L-glutamine dipeptide.
- Measured neutrophil cys-LT synthesizing capacity pre- and post-operatively.
- Compared outcomes with a control group.
Main Results:
- Neutrophil cys-LT synthesis decreased postoperatively in all patients.
- Parenteral glutamine normalized the cys-LT decrease.
- The cys-LT decrease persisted in the control group.
Conclusions:
- Parenteral glutamine provision aids in normalizing neutrophil function post-surgery.
- Restoration of neutrophil cys-LT generation is crucial for effective host defense.
- L-alanyl-L-glutamine may be beneficial in supporting immune recovery after colonic surgery.