[Use of fluoroquinolones in rheumatology]

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Published on: May 8, 2017

B S Belov, S V Shubin, V A Nasonova

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |January 1, 1996
    PubMed

    Insights

    Fluoroquinolones effectively treated infections in rheumatic disease patients, with good tolerance in most. Further studies are recommended to optimize regimens and expand their use in this population.

    Area of Science:

    • Rheumatology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Rheumatic diseases often present with concurrent infection-induced abnormalities.
    • Effective antimicrobial therapy is crucial for managing these complex cases.
    • Fluoroquinolones represent a class of antibiotics with broad-spectrum activity.

    Purpose of the Study:

    • To evaluate the efficacy and tolerance of three fluoroquinolones (ciprofloxacin, pefloxacin, lomefloxacin).
    • To assess treatment outcomes in patients with rheumatic diseases and infection-induced abnormalities.

    Main Methods:

    • A clinical study involving 157 patients with rheumatic diseases and concurrent infections.
    • Administration of ciprofloxacin, pefloxacin, or lomefloxacin.
    • Assessment of infection cure through clinical, microbiological, and serological evaluations.
    • Monitoring and categorization of drug tolerance and adverse reactions.

    Main Results:

    • An infection cure rate of 78.6% (123 out of 157 patients) was achieved.
    • Fluoroquinolone tolerance was rated as good in 72.6%, satisfactory in 23.6%, and poor in 3.8% of patients.
    • Typical adverse reactions associated with fluoroquinolones were observed.

    Conclusions:

    • Fluoroquinolones demonstrate significant efficacy in treating infections in patients with rheumatic diseases.
    • The overall tolerance profile of these fluoroquinolones is generally favorable.
    • Further clinical research is warranted to determine optimal treatment regimens and expand indications for fluoroquinolone use in this patient cohort.

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