Related Experiment Videos
[Does renal mycobacteriosis exist?]
Z Paunić1, Lj Savidjević, Z Cakić
1Institute for Kidney Disease, Zvezdara Hospital Centre, Belgrade.
Srpski Arhiv Za Celokupno Lekarstvo
|January 1, 1996
Summary
Urinary mycobacteriosis is rare, but nontuberculous mycobacteria (NTM) in urine often cause back discomfort and urinary abnormalities. Standard tuberculosis treatment is ineffective for most NTM urinary infections, necessitating susceptibility testing.
Area of Science:
- Infectious Diseases
- Nephrology
- Urology
Context:
- Nontuberculous mycobacteria (NTM) are frequently isolated from urine, but urinary mycobacteriosis is considered rare.
- Clinical presentation and laboratory findings in patients with NTM isolated from urine require further investigation.
- The efficacy of standard antituberculosis therapy for urinary NTM infections is not well-established.
Purpose:
- To evaluate the clinical course and outcomes of patients with NTM isolated from urine.
- To determine the effectiveness of standard antituberculosis therapy in treating urinary NTM infections.
- To assess the diagnostic and therapeutic implications of NTM detection in urine.
Summary:
- A study followed 63 patients with NTM in urine for 1-8 years; common symptoms included low back discomfort, pyuria, and microscopic hematuria.
- Intravenous pyelography (IVP) showed abnormalities in 72% of patients, but no clinical or laboratory progression of disease was observed during follow-up.
- Standard antituberculosis therapy was administered to 22 patients, with only 4 showing a satisfactory response, highlighting the need for susceptibility testing.
Impact:
- Detection of NTM in urine does not preclude the need to investigate other causes of hematuria or pyuria.
- Renal mycobacteriosis, if present, appears less aggressive than tuberculosis.
- Standard tuberculosis treatment regimens are often ineffective for NTM urinary infections, underscoring the importance of antimicrobial susceptibility testing for appropriate management.