Apoptosis in resolution of inflammation
1Department of Medicine, University Hospital, Nottingham, United Kingdom.
Journal of Leukocyte Biology
|April 1, 1997
Summary
Apoptosis, or programmed cell death, is crucial for resolving inflammation by clearing immune cells like neutrophils and lymphocytes. Understanding these processes may lead to new therapies for inflammatory diseases.
Area of Science:
- Immunology
- Cell Biology
- Pathology
Background:
- Inflammation resolution is critical for tissue homeostasis.
- Leukocyte accumulation contributes to inflammatory pathology.
- Programmed cell death (apoptosis) is increasingly recognized as a key resolution mechanism.
Purpose of the Study:
- To review the evidence for apoptosis in resolving acute inflammation.
- To discuss the mechanisms of leukocyte apoptosis and clearance.
- To explore the therapeutic potential of targeting these pathways.
Main Methods:
- Literature review of studies on apoptosis in inflammatory cells.
- Analysis of mechanisms regulating leukocyte apoptosis.
- Examination of phagocytic clearance of apoptotic cells.
Main Results:
- Apoptosis of neutrophils, eosinophils, lymphocytes, and monocytes promotes inflammation resolution.
- Apoptotic cells are cleared non-inflammatorily by phagocytes.
- Myofibroblast deletion via apoptosis aids in tissue remodeling.
Conclusions:
- Leukocyte apoptosis is a fundamental process in resolving acute inflammation.
- Targeting apoptosis and efferocytosis pathways offers therapeutic opportunities for inflammatory diseases.
Related Concept Videos
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Normal cells contain receptors that prevent them from being recognized by phagocytes.
Normal cells contain receptors that prevent them from being recognized by phagocytes.
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