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Updated: Jul 19, 2026
07:10
Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents
Published on: March 7, 2011
[Pleural B cell lymphoma presenting as paraplegia]
T Hashizume1, A Honda, H Shimada
1Department of Respiratory Medicine, Shizuoka General Hospital, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi
|February 1, 1997
Summary
Pleural malignant lymphoma can cause spinal cord compression leading to paraplegia. Early diagnosis and treatment are crucial for improving patient outcomes in such cases.
Area of Science:
- Oncology
- Neurology
- Pathology
Background:
- Malignant lymphoma involving the pleura is rare.
- Spinal cord compression can result from various neoplastic processes.
Observation:
- A 54-year-old man presented with chest pain, progressing to paraplegia.
- Imaging revealed a right pleural effusion and a mass compressing the spinal cord.
- Cytology and biopsy confirmed atypical B lymphocytes, diagnosing pleural malignant lymphoma.
Findings:
- The pleural mass directly invaded the spinal canal, causing cord compression.
- Chemotherapy resulted in partial remission, but the patient later died from central nervous system involvement.
Implications:
- Pleural lymphoma is a potential cause of spinal cord compression and paraplegia.
- Prompt diagnosis and intervention are critical for managing spinal cord compression secondary to pleural malignancies.
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