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[Central nervous system infection caused by mumps virus]
Nihon Rinsho. Japanese Journal of Clinical Medicine
|April 1, 1997
Summary
Mumps virus can cause severe central nervous system infections like encephalitis and deafness. Mumps vaccination is crucial for preventing these serious complications and is still important despite vaccine availability.
Area of Science:
- Neurology
- Virology
- Infectious Diseases
Context:
- Mumps virus is a significant cause of central nervous system (CNS) infections.
- CNS complications include aseptic meningitis, encephalitis, hydrocephalus, ataxia, transverse myelitis, Guillain-Barré syndrome, and deafness.
- While preventable by vaccination, mumps remains a common communicable viral infection.
Purpose:
- To review central nervous system complications of mumps virus infection.
- To highlight the impact of mumps vaccine strains on aseptic meningitis.
- To discuss advancements in differentiating wild and vaccine mumps virus strains.
Summary:
- Mumps virus infection can lead to severe neurological sequelae, including acute and chronic encephalitis, hydrocephalus, transverse myelitis, and deafness.
- An increase in mumps vaccine strain-associated aseptic meningitis was observed post-introduction of the measles, mumps, and rubella (MMR) vaccine in Japan.
- Molecular analysis now allows for differentiation between wild and vaccine mumps virus strains.
Impact:
- Emphasizes the critical role of mumps vaccination in preventing severe neurological complications such as encephalitis and deafness.
- Highlights the ongoing public health importance of mumps prevention strategies.
- Informs clinicians and public health officials about the spectrum of mumps-related CNS disease and diagnostic advancements.