Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Prion diseases--general aspect]

Y Kuroda1, M Matsui

  • 1Department of Internal Medicine, Saga Medical School.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|April 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Application of oral tolerance to the treatment of autoimmune diseases--active suppression and bystander suppression].

Nihon rinsho. Japanese journal of clinical medicine·1997
Same author

Construction and expression of chimeric rat liver hydroxysteroid sulfotransferase isozymes.

Archives of biochemistry and biophysics·1997
Same author

High sulfotransferase activity for phenolic aromatic odorants present in the mouse olfactory organ.

Chemico-biological interactions·1997
Same author

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1.

Proceedings of the National Academy of Sciences of the United States of America·1997
Same author

Expression analysis of mortalin, a unique member of the Hsp70 family of proteins, in rat tissues.

Experimental cell research·1997
Same author

[Progressive rubella panencephalitis].

Nihon rinsho. Japanese journal of clinical medicine·1997

Prion diseases involve abnormal prion protein (PrP) accumulation in the brain. While normal PrP function is unclear, abnormal PrP causes infectious diseases like Creutzfeldt-Jakob disease (CJD).

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Context:

  • Prion diseases are neurodegenerative disorders.
  • Characterized by abnormal prion protein (PrP) accumulation in the brain.
  • PrP is a host gene-encoded glycoprotein essential for cell membrane function.

Purpose:

  • To describe the characteristics of prion diseases.
  • To differentiate between hereditary and sporadic forms.
  • To highlight the infectious nature and transmission routes of sporadic prion diseases like Creutzfeldt-Jakob disease (CJD).

Summary:

  • Prion diseases stem from misfolded prion protein (PrP) accumulation.
  • Hereditary forms have 16 known pathogenic PrP gene mutations.
  • Sporadic forms, like CJD, are infectious, with potential iatrogenic and bovine spongiform encephalopathy transmission routes.

Related Experiment Videos

Impact:

  • Understanding PrP's role in neurodegeneration.
  • Clarifying disease mechanisms and transmission.
  • Informing diagnostic and therapeutic strategies for prion diseases.