[Multiple malignant tumours in gynaecology (author's transl)]

Area of Science:

• Oncology
• Gynaecology
• Epidemiology

Context:

• Analysis of 8500 malignant tumors treated between 1950-1975.
• Focus on multiple primary neoplasms in gynecological cancer patients.
• Data collected from the radiotherapy unit of the Ist Department of Gynaecology, University of Vienna.

Purpose:

• To investigate the incidence and patterns of multiple primary neoplasms in women with gynecological malignancies.
• To characterize the location and timing of secondary tumors relative to the primary gynecological cancer.
• To compare observed findings with existing literature on neoplasm multiplicity.

Summary:

• 2.4% (204/8500) of observed malignant tumors were multiple primary neoplasms.
• Local multiplicity within the genital region occurred in 37.2% (76/204) of cases.
• Distant secondary neoplasms were observed in 128 cases, with breast cancer being the most frequent (61 cases, 29.9%).
• One-third of multiple neoplasms were diagnosed simultaneously; two-thirds occurred within one year before or after the primary diagnosis.
• Seven cases of triple neoplasms were analyzed separately.

Impact:

• Provides epidemiological data on the occurrence of multiple primary cancers in gynecological oncology.
• Highlights the significance of breast cancer as a common secondary site in this patient population.
• Informs clinical surveillance and diagnostic strategies for patients with gynecological malignancies, considering the risk of secondary primaries.