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Related Experiment Videos

Relationship between napping and melatonin in the blind

S W Lockley1, D J Skene, H Tabandeh

  • 1Chronobiology Laboratory, School of Biological Sciences, University of Surrey, Guildford, United Kingdom.

Journal of Biological Rhythms
|February 1, 1997
PubMed
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Abnormally timed melatonin rhythms in blind individuals correlate with increased daytime napping and sleepiness. Normalizing melatonin timing improved night sleep and reduced daytime naps.

Area of Science:

  • Chronobiology
  • Sleep Medicine
  • Neuroendocrinology

Background:

  • Daytime sleepiness is prevalent in visually impaired individuals.
  • Disrupted melatonin secretion is a suspected cause of sleep disturbances in blindness.

Purpose of the Study:

  • To investigate the relationship between endogenous melatonin rhythms and daytime napping patterns in subjects with no conscious light perception (NPL).

Main Methods:

  • 15 NPL subjects were monitored for one month.
  • Melatonin rhythms (6-sulphatoxymelatonin, aMT6s) and napping behavior were assessed.
  • Cosinor and regression analyses were employed.

Main Results:

  • 9/15 subjects exhibited free-running melatonin rhythms; 3 had abnormal phase entrainment.

Related Experiment Videos

  • Most subjects (13/15) took daytime naps, with more frequent and longer naps in those with abnormal melatonin rhythms.
  • Nap timing correlated significantly with melatonin rhythm phase, particularly around the aMT6s acrophase.

    • Conclusions:

    • Abnormally timed endogenous melatonin secretion is strongly linked to daytime sleepiness and napping in blind individuals.
    • Melatonin timing influences sleep-wake patterns, affecting both night sleep duration and daytime napping frequency.