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Updated: Aug 10, 2026
04:30
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Coronary stenting (Cordis) without anticoagulation
1Department of Internal Medicine, University of Ulsan, College of Medicine, Seoul, Korea.
The American Journal of Cardiology
|April 1, 1997
Summary
Aspirin and ticlopidine combination therapy after Cordis coronary stent implantation significantly reduced stent thrombosis compared to aspirin alone. This antiplatelet regimen is a promising alternative to anticoagulation.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Biomaterials Science
Background:
- The Cordis coronary stent is a flexible, balloon-expandable, radiopaque tantalum stent used in interventional cardiology.
- Subacute thrombosis and clinical outcomes after coronary stenting are influenced by antithrombotic regimens.
- Optimizing antithrombotic therapy is crucial for improving patient outcomes following stent implantation.
Purpose of the Study:
- To evaluate the impact of different antithrombotic regimens on subacute thrombosis and short-term clinical courses after Cordis coronary stent implantation.
- To compare the efficacy and safety of combined aspirin and ticlopidine therapy versus aspirin alone and aspirin, ticlopidine, and warfarin regimens.
Main Methods:
- A prospective study involving 275 patients undergoing 356 Cordis stent implantations.
- Patients were divided into three groups based on post-stent antithrombotic regimen: Group 1 (aspirin, ticlopidine, warfarin), Group 2 (aspirin, ticlopidine), and Group 3 (aspirin alone).
- Outcomes assessed included procedural success rates and the incidence of stent thrombosis.
Main Results:
- Overall procedural success rates were high across all groups (97.7% to 100%).
- The incidence of stent thrombosis was lowest in the aspirin and ticlopidine group (0%), intermediate in the aspirin, ticlopidine, and warfarin group (1.2%), and highest in the aspirin alone group (6.8%).
- Aspirin monotherapy was associated with a significantly higher rate of stent thrombosis.
Conclusions:
- The Cordis coronary stent is effective for various clinical indications, including unstable angina and acute myocardial infarction.
- Antiplatelet therapy with aspirin and ticlopidine is a safe and effective alternative to anticoagulation after Cordis stenting, reducing thrombosis risk.
- Aspirin monotherapy post-Cordis stenting is associated with a substantial risk of stent thrombosis and should be used cautiously.
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