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Related Experiment Videos

Mouse paw preference: effects of variations in testing protocol

M B Bulman-Fleming1, M P Bryden, T T Rogers

  • 1Department of Psychology, University of Waterloo, Ontario, Canada. bfleming@watarts.uwaterloo.ca

Behavioural Brain Research
|June 1, 1997
PubMed
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Mouse paw preference lateralization is influenced by testing protocols. More consistent paw preference emerged with fewer reaches per session, despite practice effects and no sex or tube size impact.

Area of Science:

  • Neuroscience
  • Animal Behavior
  • Ethology

Background:

  • Paw preference, a measure of lateralization, is crucial for understanding motor control.
  • Previous research has explored factors influencing paw preference, but protocol effects require further investigation.

Purpose of the Study:

  • To investigate the impact of different testing protocols on mouse paw preference.
  • To examine the independence of reaches, practice effects, sex differences, and tube size in mouse paw preference.

Main Methods:

  • Two inbred mouse strains (C57BL/6J and BALB) were used across two experiments.
  • The Collins paw preference apparatus was employed to record paw reaches under two protocols: I (2 reaches/day for 25 days) and S (50 reaches/session).

Main Results:

Related Experiment Videos

  • Higher lateralization was observed under the I protocol compared to the S protocol.
  • No evidence of non-independent reaches was found under the S protocol.
  • Practice led to slight increases in lateralization; sex and tube size had no significant effect.
  • A significant protocol x order interaction indicated that the sequence of testing influenced lateralization outcomes.

Conclusions:

  • Testing protocol significantly impacts the measurement of mouse paw preference and lateralization.
  • The I protocol appears more sensitive for detecting stable paw preference than the S protocol.
  • Understanding protocol-dependent effects is essential for accurate interpretation of mouse lateralization studies.