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The HPV determinants of CIN I
M A Duggan1, S E McGregor, G C Stuart
1Department of Pathology, Foothills Hospital, Alberta, Canada.
European Journal of Gynaecological Oncology
|January 1, 1997
Summary
Human papillomavirus (HPV) infection is common in women with cervical intraepithelial neoplasia grade I (CIN I). HPV is sexually transmitted and influences cervical cancer risk, even with co-occurring high-grade lesions.
Area of Science:
- Gynecology
- Oncology
- Virology
Background:
- Cervical intraepithelial neoplasia grade I (CIN I) is often detected via Pap tests.
- Human papillomavirus (HPV) is a primary cause of cervical lesions.
- Understanding HPV's role in CIN I is crucial for cervical cancer prevention.
Purpose of the Study:
- To investigate HPV correlates in women with CIN I.
- To assess the impact of co-incident CIN II/III lesions on HPV status.
- To determine HPV determinants in screening-detected CIN I.
Main Methods:
- 537 women with CIN I on Pap tests were categorized into two groups based on colposcopy and repeat Pap.
- Group A: /= CIN II (n=195).
- HPV typing via PCR amplification of cervical scrapes; clinical, demographic, reproductive, and risk factors collected.
Main Results:
- HPV positivity was 47% overall; types 16/18 were most common (28%).
- Group B showed slightly higher HPV positivity (52%) due to increased HPV 16/18.
- No significant correlates identified, but HPV-positive women were younger with more partners.
Conclusions:
- Co-incident CIN II/III lesions can inflate HPV prevalence in CIN I.
- HPV appears sexually transmitted in both low and high-grade cervical lesions.
- HPV's role in CIN I is consistent, unaffected by co-existing higher-grade lesions.