Related Experiment Video
Updated: Oct 13, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
Parenteral use of diazepam in an emulsion formulation. A clinical study
Abstract:
A recently described injection formulation for diazepam, consisting of an oil emulsion where the drug is dissolved in the oil phase, has been found to give a lessened degree of side reactions than commercially available preparations. This emulsion formulation was compared to Valium inj. as premedication in patients undergoing operation for hernia or varices under epidural anaesthesia. The effects, measured as the degree of drowsiness according to an arbitrary scale, were found to be equal for the two formulations. Neither was there any difference in blood concentrations in the two application groups, respectively, between the preparations used. The propylene glycol content of Valium inj. is said to cause a delayed release of the drug from the injection site after i.m. application, and this is briefly discussed, as well as the possibility of administering the diazepam emulsion continuously, diluted with Intralipid, without the risk of precipitation.
More Related Videos
Related Concept Videos
Parenteral Anesthetics: Overview
Anxiolytic Drugs: Benzodiazepines and Buspirone
Drug Delivery: Enteral Route
Drugs in...
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Bioavailability Enhancement: Drug Permeability Enhancement
Ophthalmic Drug Delivery Systems

