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Spindle-shaped, cross-banded structures in human peripheral nerves

H Tohgi, M Tabuchi, M Tomonaga

    Acta Neuropathologica
    |September 26, 1977
    PubMed
    Summary

    Fibrous long-spacing collagen, also known as Luse bodies, were identified in human peripheral nerves. These structures exhibit unique cross-bandings and their presence in nerve tissue is discussed.

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    Area of Science:

    • Neuroscience
    • Cell Biology
    • Connective Tissue Research

    Background:

    • Fibrous long-spacing collagen (FLS) represents an unusual form of collagen.
    • Luse bodies are characterized by their distinct fusiform and cross-banded appearance.
    • The presence and role of FLS in peripheral nerves remain incompletely understood.

    Purpose of the Study:

    • To investigate the occurrence and characteristics of fibrous long-spacing collagen (Luse bodies) in human peripheral nerves.
    • To describe the morphological features and localization of these structures within nerve tissue.
    • To discuss the potential origin and pathological significance of Luse bodies in the peripheral nervous system.

    Main Methods:

    • Histological examination of nerve samples from the short saphenous vein and sural nerve in humans.
    • Ultrastructural analysis to characterize the morphology and periodicity of the observed banded structures.
    • Localization studies to determine the relationship between Luse bodies and cellular components like Schwann cells and fibroblasts.

    Main Results:

    • Fusiform, cross-banded structures consistent with fibrous long-spacing collagen (Luse bodies) were identified.
    • The periodicity of the cross-bandings ranged from 140-170 nm, lacking intraperiod striation.
    • These structures were observed both isolated within endoneurial spaces and adjacent to Schwann cells or fibroblasts.

    Conclusions:

    • Fibrous long-spacing collagen (Luse bodies) can be found in human peripheral nerves, associated with vascular and nerve tissues.
    • The observed morphology and localization suggest potential interactions with Schwann cells and fibroblasts.
    • Further research is warranted to elucidate the precise origin and pathological implications of Luse bodies in peripheral nerve.

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