Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sepsis and septic shock

G Zanetti1, J D Baumgartner, M P Glauser

  • 1Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne.

Schweizerische Medizinische Wochenschrift
|March 22, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tarlov cyst: A rare cause of posterior mediastinal mass.

Pulmonology·2019
Same author

CT halo sign in pulmonary metastases from a melanoma.

QJM : monthly journal of the Association of Physicians·2018
Same author

Morphological characteristics of the reversed halo sign that may strongly suggest pulmonary infarction.

Clinical radiology·2017
Same author

Universal screening and decolonization for control of MRSA in nursing homes: follow-up of a cluster randomized controlled trial.

The Journal of hospital infection·2017
Same author

High resolution computed tomography of the chest in the evaluation of patients with Birt-Hogg-Dubé syndrome.

Revista portuguesa de pneumologia·2017
Same author

Textiloma: A forgotten diagnosis.

Revista portuguesa de pneumologia·2016
Same journal

Respiratory function test in the case of temporary phrenic nerve contusion, associated with pneumoperitoneum; About the diagnostic value of laparoscopy.

Schweizerische medizinische Wochenschrift·2010
Same journal

Treatment of pulmonary tuberculosis and pleurisy by means of temporary paralysis of the diaphragm, supported by the pneumoperitoneum.

Schweizerische medizinische Wochenschrift·2010
Same journal

Boeck's disease as a tuberculous syndrome.

Schweizerische medizinische Wochenschrift·2010
Same journal

Enteral primary tubercular complexes

Schweizerische medizinische Wochenschrift·2010
Same journal

Tuberculous stenoses of the large bronchi.

Schweizerische medizinische Wochenschrift·2010
Same journal

About the enzyme action.

Schweizerische medizinische Wochenschrift·2010
See all related articles

Sepsis and septic shock are systemic infections with increasing incidence. Understanding their pathophysiology and bacterial triggers is key, but current therapies, including novel approaches, are not yet routinely applicable.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Pathophysiology

Background:

  • Focal infections can lead to systemic syndromes like sepsis, severe sepsis, and septic shock.
  • The incidence of sepsis and septic shock has risen, with a stable ratio of gram-negative to gram-positive bacteria.
  • Standardized definitions aid diagnosis but should complement clinical and microbiological assessments.

Purpose of the Study:

  • To review the pathophysiology of sepsis and septic shock.
  • To discuss current and emerging therapeutic strategies.
  • To highlight the role of bacterial products in triggering inflammatory responses.

Main Methods:

  • Literature review of sepsis pathophysiology and treatment.
  • Analysis of trends in sepsis incidence and causative organisms.

Related Experiment Videos

  • Discussion of molecular mechanisms involving bacterial products and host inflammatory responses.

    • Main Results:

    • Bacterial products (lipopolysaccharide, exotoxins, cell wall fragments) directly trigger or stimulate cells to produce pro-inflammatory cytokines.
    • Antibiotics and surgical intervention remain the cornerstone of sepsis management.
    • Emerging therapies targeting inflammatory mediators have not yet yielded routine clinical applications.

    Conclusions:

    • Sepsis and septic shock result from complex inflammatory pathways initiated by infectious agents.
    • While understanding has advanced, effective routine therapies beyond foundational treatments are still under development.
    • Continued research into inhibiting inflammatory mediators is crucial for future sepsis management.