Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

c-Jun and GST-pi expression in human plasma cells

D Di Simone1, S Galimberti, L Mattii

  • 1Department of Oncology, University of Pisa, Italy.

Haematologica
|January 1, 1997
PubMed
Summary

This study found high expression of c-Jun and glutathione-S-transferase pi (GST-pi) in both patients with multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS), and healthy controls. This suggests a potential role for the AP-1 complex in GST-pi regulation in plasma cells.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Second-line therapies after CDK4/6 inhibitor failure in HR-positive/HER2-negative metastatic breast cancer patients: real-world data from the HERMIONE-13 study.

ESMO real world data and digital oncology·2026
Same author

Choice of Frontline Tyrosine-Kinase Inhibitor and Early Events in Very Elderly Patients With Chronic Myeloid Leukemia in Chronic Phase: A "Campus CML" Study.

European journal of haematology·2024
Same author

Chronic lip edema and pain secondary to lip augmentation procedure: histological, scanning electron microscopy and X-ray microanalysis evaluation.

European review for medical and pharmacological sciences·2023
Same author

Treatment discontinuation following low-dose TKIs in 248 chronic myeloid leukemia patients: Updated results from a campus CML real-life study.

Frontiers in pharmacology·2023
Same author

Carboxytherapy with oxygen propulsion treatment of cellulite is more effective in women not affected by periodontal disease.

Journal of biological regulators and homeostatic agents·2021
Same author

Contributi scientifici in memoria di Antonio Fusco.

La Clinica terapeutica·2020

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) are plasma cell disorders.
  • The transcription factor AP-1, including its component c-Jun, plays a role in cellular processes.
  • Glutathione-S-transferase pi (GST-pi) is involved in cellular detoxification and can be regulated by transcription factors.

Purpose of the Study:

  • To investigate the expression of c-Jun and GST-pi in plasma cells from patients with MM and MGUS.
  • To explore the potential relationship between c-Jun and GST-pi expression.
  • To assess the correlation of c-Jun and GST-pi expression with clinical and laboratory data.

Main Methods:

  • Immunocytochemical analysis was performed on bone marrow samples.

Related Experiment Videos

  • Expression levels of c-Jun and GST-pi were quantified.
  • Statistical analysis was used to determine correlations.

    • Main Results:

    • High and frequent expression of both c-Jun and GST-pi was observed in MM and MGUS patients.
    • Similar high expression levels of c-Jun and GST-pi were found in control subjects.
    • No statistically significant correlation was found between c-Jun and GST-pi expression, nor with clinical/laboratory data.

    Conclusions:

    • The study confirms a high prevalence of c-Jun and GST-pi expression in human plasma cells, irrespective of disease status.
    • Results suggest a potential role for the AP-1 complex in the activation of the GST-pi promoter in plasma cells.
    • Further research is warranted to elucidate the precise functional significance of AP-1 and GST-pi in plasma cell biology.