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Venous and arterial thrombophilia
A Girolami1, P Simioni, L Scarano
1Institute of Medical Semeiotics, University of Padua Medical School, Italy.
Haematologica
|January 1, 1997
Summary
Thrombophilic states predispose to both venous and arterial thrombosis, though venous events are more common. Vessel condition and triggering factors are crucial in thrombosis development.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Thrombosis Research
Background:
- A thrombophilic state is a condition predisposing individuals to thrombosis.
- While venous and arterial thrombosis pathogenesis may differ, they can coexist in thrombophilic patients.
Purpose of the Study:
- To critically analyze the thrombophilic state.
- To define a rational approach for managing patients with venous and/or arterial thrombosis.
Main Methods:
- Review of personal research and published articles from Science Citation Index journals.
Main Results:
- Thrombophilic states like APC resistance, protein C/S defects, and antiphospholipid antibody syndrome can cause both venous and arterial thrombosis.
- Venous thrombosis is more frequent but less severe than arterial thrombosis in these conditions.
- Antithrombin deficiency predominantly links to venous thrombosis.
Conclusions:
- Vessel status and triggering factors significantly influence thrombosis occurrence.
- Laboratory tests do not reliably predict arterial versus venous thrombosis, except for increased blood viscosity often indicating arterial events.
- The thrombophilic state is a unified entity, with thrombosis location influenced by vessel condition and triggers.