Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dendritic cells and T lymphocytes: developmental and functional interactions

K Shortman1, L Wu, G Süss

  • 1Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.

Ciba Foundation Symposium
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland-Does Variation Matter?

Pediatric blood & cancer·2026
Same author

Global assessment of partial artemisinin resistance: multicenter trial across Kenya, Peru, and Thailand in patients with uncomplicated Plasmodium falciparum malaria.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2025
Same author

Pragmatic clustered randomised control trial to evaluate a self-regulated learning intervention to be implemented in South Australian primary schools-study protocol.

Trials·2025
Same author

Comparative effectiveness of interventions for cancer treatment-related cognitive impairment in adult cancer survivors: protocol for a systematic review.

Systematic reviews·2024
Same author

The Patient's perspective: A review of the results from a radiotherapy patient experience survey in the North-West of England.

Radiography (London, England : 1995)·2023
Same author

Comparison of multimodal analgesia with thoracic epidural after transthoracic oesophagectomy.

The British journal of surgery·2021
Same journal

Precision agriculture: spatial and temporal variability of environmental quality. General reflections.

Ciba Foundation symposium·1997
Same journal

Uncertainty in hydrogeological modelling.

Ciba Foundation symposium·1997
Same journal

Optimal mapping of site-specific multivariate soil properties.

Ciba Foundation symposium·1997
Same journal

Modelling for precision weed management.

Ciba Foundation symposium·1997
Same journal

GIS support for precision agriculture: problems and possibilities.

Ciba Foundation symposium·1997
Same journal

Spatial sampling.

Ciba Foundation symposium·1997
See all related articles

A subset of dendritic cells (DCs) originate from lymphoid precursors, not myeloid ones, challenging existing understanding. These lymphoid-derived DCs play a regulatory role in T cell responses.

Area of Science:

  • Immunology
  • Cell Biology
  • Developmental Biology

Background:

  • Dendritic cells (DCs) are crucial for T cell activation and antigen presentation.
  • DCs are typically considered myeloid-derived, but evidence suggests a lymphoid origin for some subsets.
  • The origin and function of thymic and splenic DCs require further investigation.

Purpose of the Study:

  • To investigate the origin of a specific subgroup of dendritic cells (DCs).
  • To characterize the functional properties of lymphoid-derived DCs.
  • To determine the role of these DCs in T cell regulation.

Main Methods:

  • Analysis of early thymic T cell precursors.
  • Cell transfer experiments in irradiated recipients.
  • Cytokine-driven in vitro culture of thymic DCs.

Related Experiment Videos

  • Functional assays on CD8+ DCs in mouse spleen.

    • Main Results:

    • Early thymic T cell precursors can generate T cells, B cells, NK cells, and DCs, but not myeloid cells.
    • These precursors produce thymic DCs in culture without GM-CSF.
    • A subgroup of splenic DCs expressing CD8 alpha alpha homodimers may also be lymphoid-derived.
    • These CD8+ DCs exhibit distinct functional properties, including T cell activation followed by Fas ligand-mediated killing and restricted CD8+ T cell proliferation due to insufficient IL-2 production.

    Conclusions:

    • A subgroup of dendritic cells, particularly in the thymus and potentially in other lymphoid organs, are of lymphoid origin.
    • These lymphoid-derived CD8+ DCs possess unique functional characteristics that suggest a regulatory role in T cell responses, distinct from conventional DCs.