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Decrease in Le(x) expression in esophageal adenocarcinomas arising in Barrett's epithelium

U Engel1, R McCombs, P Stranahan

  • 1State University Hospital, Copenhagen, Denmark.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
|April 1, 1997
PubMed
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Researchers studied Lewis y (Le(x)) antigen expression in esophageal adenocarcinoma. Loss of Le(x) was significantly associated with Barrett's esophagus, potentially aiding in monitoring malignant progression.

Area of Science:

  • Gastroenterology
  • Oncology
  • Biochemistry

Background:

  • Barrett's esophagus is a precursor to esophageal adenocarcinoma.
  • Aberrant glycosylation, including Lewis antigen expression, is observed in cancers.
  • Le(x) antigen expression patterns in Barrett's-associated adenocarcinoma require further investigation.

Purpose of the Study:

  • To investigate the expression of Lewis a (Le(a)), Lewis y (Le(x)), and combined Le(a)-Le(x) antigens in esophageal adenocarcinomas.
  • To compare Le(x) expression between adenocarcinomas arising in Barrett's epithelium and those without Barrett's.

Main Methods:

  • Immunohistochemical analysis of Le(a), Le(x), and Le(a)-Le(x) expression in 50 esophageal adenocarcinomas.
  • Categorization of tumors based on origin: 17 from Barrett's epithelium and 33 without.

Related Experiment Videos

  • Statistical analysis to determine correlations between antigen expression and tumor origin.

    • Main Results:

    • A significant decrease in Le(x) expression was observed in Barrett's-associated adenocarcinomas compared to non-Barrett's.
    • 59% of Barrett's adenocarcinomas were Le(x) negative versus 24% of non-Barrett's.
    • Le(x) expression decreased progressively from normal to dysplastic to cancerous tissue in the Barrett's group, unlike the non-Barrett's group.

    Conclusions:

    • Reduced Le(x) expression is a distinguishing feature of esophageal adenocarcinomas arising in Barrett's esophagus.
    • Le(x) antigen expression may serve as a biomarker for monitoring disease progression in Barrett's esophagus patients.
    • Le(a) and Le(a)-Le(x) expression did not differ significantly between the two groups.