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Sexual behaviour and increased anal cancer

R J Ablin¹, R Stein-Werblowsky

¹Innapharma Inc., Upper Saddle River, New Jersey 07458-1935, USA.

Immunology and Cell Biology

|April 1, 1997

Summary

Epidermoid anal cancer has increased, particularly in women. This study suggests spermatozoa and seminal plasma, not just HIV and human papillomaviruses, may be key factors, highlighting anal intercourse as a primary risk.

Area of Science:

Oncology
Epidemiology
Gastroenterology

Background:

Epidermoid anal cancer incidence has risen significantly between 1959-1989.
This rise is more pronounced in women compared to men.
Previous studies show no significant interaction between HIV, human papillomaviruses, and anal cancer incidence.

Purpose of the Study:

To explore alternative etiological agents contributing to the observed increase in anal cancer.
To investigate the role of spermatozoa and seminal plasma as potential etiological factors or cofactors in anal cancer development.
To identify sexual behavior, specifically anal intercourse, as a primary factor in anal cancer etiology.

Main Methods:

Review of epidemiological data on anal cancer trends (1959-1989).

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Analysis of potential etiological agents and cofactors in anal cancer.

Correlation of sexual practices, particularly anal intercourse, with anal cancer incidence.

Main Results:

Spermatozoa and seminal plasma are proposed as potential etiological agents or cofactors in anal cancer.
Anal intercourse is identified as a primary factor in the development of anal cancer.
The study suggests that sexual behavior, not sexual preference, is a key determinant.

Conclusions:

The rise in epidermoid anal cancer necessitates exploring factors beyond HIV and human papillomaviruses.
Spermatozoa and seminal plasma warrant further investigation as contributors to anal cancer.
Anal intercourse is implicated as a significant risk factor for anal cancer, irrespective of sexual preference.